At Hilinski MedSpa in San Diego, we take pride in offering cutting-edge, non-surgical treatments that rejuvenate your skin from within. Injectable Platelet-Rich Fibrin (PRF) is one of the most advanced options for restoring youthful vitality and improving skin texture, tone, and elasticity. Using your own blood, PRF naturally stimulates collagen production and tissue regeneration for long-term skin rejuvenation and natural-looking results.1
While PRF can be performed on its own, it’s also commonly used to enhance the results of EZ Gel, another regenerative treatment derived from your own blood components that adds gentle volume for a more complete facial refresh.
Discover the Science Behind Injectable PRF
Natural Rejuvenation Redefined
Platelet-Rich Fibrin is a next-generation form of platelet-rich plasma (PRP), created by processing a small sample of your own blood through a specialized centrifuge. This technique separates the blood into a layer rich in platelets, white blood cells, and fibrin—components that naturally encourage the release of growth factors over time. These growth factors trigger new collagen production, enhance tissue regeneration, and improve skin health across multiple areas of the face.
Unlike dermal fillers made with hyaluronic acid, PRF contains no additives or synthetic substances, eliminating concerns about allergic reactions. The result is a biocompatible, cutting-edge treatment that revitalizes the skin from within while maintaining your body’s natural harmony.
The Advantages of Choosing Injectable PRF for Your Aesthetic Goals
Natural Regeneration
PRF uses your own blood to deliver concentrated growth factors that restore firmness, smooth fine lines, and improve overall skin texture for soft, radiant facial rejuvenation.2
Enhanced Skin Health
PRF improves elasticity and refines tone for patients with acne scars, uneven skin, or volume loss.3 It’s a natural way to support long-term skin rejuvenation and youthful vibrance.
Safe & Biocompatible
Because PRF is 100% autologous—derived entirely from your own blood—there is minimal risk of allergic reactions, making it a safe option for nearly any good candidate seeking natural enhancement.
Long-Lasting Results
PRF promotes continuous release of growth factors, encouraging new collagen and stronger skin structure. These gradual improvements deliver visible, long-lasting results that enhance your appearance over time.
A Step-by-Step Guide to the PRF Procedure at Hilinski MedSpa
Personalized Consultation
Your PRF journey begins with a personalized consultation, where a qualified provider will assess your skin and discuss your aesthetic goals—such as softening fine lines, brightening the under-eye area, or improving overall skin texture. During this visit, your provider will determine if you’re a good candidate for PRF therapy and develop a customized treatment plan to help you achieve smooth, natural-looking results.
Blood Draw & Processing
A small blood draw is performed, similar to a routine lab test. The sample is placed in a centrifuge, where it’s spun at a precise speed to separate the platelet-rich fibrin layer from the rest of the blood.
Preparation of PRF
The collected PRF contains high concentrations of white blood cells, platelets, and fibrin mesh that hold the growth factors responsible for collagen stimulation and tissue regeneration.
Precise Injection Technique
PRF is carefully injected into targeted areas of the face—such as the under-eye region, cheeks, nasolabial folds, or jawline—to naturally enhance firmness and smoothness.
Targeted Treatment Areas: Where Injectable PRF Can Make a Difference
Injectable PRF can address a variety of aesthetic concerns, including:
- Under-eye hollows and discoloration
- Fine lines and wrinkles, including the delicate areas around the eyes4
- Smile lines and marionette folds
- Dull or uneven skin texture
- Volume loss in the cheeks or temples
- Acne scars and sun damage
- Early signs of aging on the neck and décolletage
Beyond facial rejuvenation, PRF can also be used for hair restoration, helping stimulate new hair growth and reduce hair loss by encouraging the same regenerative growth factors to repair follicles.
Comparing Injectable PRF to Other Rejuvenation Options
Traditional dermal fillers and hyaluronic acid products provide instant enhancement but rely on synthetic materials. Injectable PRF works differently—it gradually renews the skin through natural collagen production and sustained tissue regeneration, offering subtle, long-lasting improvement in tone and texture. This approach appeals to those seeking natural rejuvenation without synthetic substances or immediate filler effects.
Injectable PRF Recovery & Results
One of the best features of PRF is its minimal downtime. You might experience slight redness or swelling for 24–48 hours, but these effects fade quickly. Most patients return to daily routines right away.
Improvements appear gradually as the skin’s collagen production increases and growth factors continue to rebuild healthy tissue. Expect firmer, smoother skin and a radiant glow that can last 9–12 months or longer. Many patients schedule routine PRF treatments to maintain their refreshed look and overall skin health.
Injectable PRF FAQs
While both use your own blood, PRF is spun at a lower speed in the centrifuge, allowing more platelets, white blood cells, and fibrin to remain. This results in a slower release of growth factors and stronger collagen remodeling for longer-lasting outcomes.
Absolutely. PRF works beautifully alongside BOTOX, microneedling, dermal fillers, and laser treatments to enhance results. Your provider will create a customized treatment plan to target specific areas of the face or complement your ongoing skincare routine.
Results typically last between 9–12 months, with continued improvements in skin texture, tone, and firmness over time. Regular PRF therapy helps sustain youthful, natural-looking results.
Ideal candidates are individuals experiencing fine lines, volume loss, acne scars, or early signs of aging who prefer a non-surgical approach using their own blood.
Most patients experience minimal downtime, with only mild redness or swelling that resolves within a couple of days.
Yes. PRF treatment is also effective for hair restoration by stimulating hair growth in thinning areas. The same growth factors that rejuvenate the skin can help strengthen follicles and reduce hair loss.
The cost of Injectable PRF varies depending on your personalized treatment plan, the number of sessions recommended, and the specific areas of the face or scalp being treated. During your consultation at our San Diego Med Spa, your provider will review your aesthetic goals and develop a customized approach that fits your needs. Many patients find that PRF treatment offers excellent long-term value due to its ability to stimulate natural collagen production, improve skin rejuvenation, and deliver lasting, natural-looking results.
Why San Diego and La Jolla Patients Trust Hilinski MedSpa
Led by Dr. John Hilinski, a board-certified facial plastic surgeon, our Med Spa combines medical precision with an artistic approach to rejuvenation. Whether you’re interested in PRF therapy, injectables, or comprehensive skincare treatments, our team in San Diego and La Jolla delivers exceptional care and personalized attention to help you achieve your aesthetic goals.
Experience Natural Rejuvenation with Injectable PRF
If you’re ready to refresh your skin and restore youthful vitality with a natural, non-surgical solution, schedule your PRF treatment consultation at Hilinski MedSpa in San Diego today. Our expert team will design a plan tailored to your skin, lifestyle, and wellness goals for glowing, long-lasting results.
Sources
1 Dermatologic Therapy. Platelet-Rich Fibrin as an Effective Method of Skin Revitalization. https://onlinelibrary.wiley.com/doi/10.1155/2023/9040608. Accessed November 12, 2025.
2 Indian Dermatology Online Journal. Platelet-Rich Fibrin, Preparation and Use in Dermatology. https://pmc.ncbi.nlm.nih.gov/articles/PMC8664174/. Accessed November 12, 2025.
3 Qin N, Kochheiser M, Akosman I, Dugue D, Raghunandan A, Pavuluri C, Gundlach C, Vaeth AM, Wei L, Wesorick BR, Otterburn DM. Systematic Review of Platelet-Rich Plasma and Platelet-Rich Fibrin in Facial Rejuvenation. Ann Plast Surg. 2025 Apr 1;94(4S Suppl 2):S376-S389. doi: 10.1097/SAP.0000000000004267. PMID: 40167104. Available: https://pubmed.ncbi.nlm.nih.gov/40167104/. Accessed November 12, 2025.
4 Mahmoodabadi RA, Golafshan HA, Pezeshkian F, Shahriarirad R, Namazi MR. Evaluation of the Effect of Platelet-Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial. Dermatol Pract Concept. 2023 Jan 1;13(1):e2023050. doi: 10.5826/dpc.1301a50. PMID: 36892335; PMCID: PMC9946120. Available: https://pmc.ncbi.nlm.nih.gov/articles/PMC9946120/. Accessed November 12, 2025.